The aim of the project is to study the behavior of ABC transporters (biological agents responsible for removing drugs and other toxins from human cells) in microgravity conditions.
To achieve these conditions, the experiment was carried out through a series of parabolic flights of ESA.
Once in conditions of weightlessness there are performed experiments that evaluate the activity of the ABC transporter family. In recent years we have been developing a protocol that will allow us to accurately measure ABC transporter activity during parabolic flights.
We performed an experiment in normal gravity to compare whether the gravitational forces are capable of affecting the activity of the transporter. To further understand the mechanism of action of the transporters they will use inhibitors capable of regulating the tranporter function.